BoARI

Burden of Acute Respiratory Illness among Healthcare Workers in Kenya

BoARI Study
Study Duration
24 months

2023 – 2025

Project Locations
12 counties

500 locations

Lead Researchers

Prof. Kariuki Njenga – WSU

Dr. Nancy Otieno – KEMRI

Dr. Gideon Emukule – CDC

Study Participants

Healthcare Workers

Background & Rationale

Acute respiratory illnesses (ARIs) are diseases of the respiratory system that are of sudden onset (history of ≤10 days). Symptoms include – cough (new or worsening cough), runny nose, sore throat, shortness of breath, and chills or hotness of the body. The ARIs are the leading cause of morbidity and mortality; and the overall burden of disease based on disability-adjusted life years (DALY). Common causes include viruses (influenza, RSV, rhinoviruses, adenovirus, coronaviruses, etc.), bacteria (S. pneumoniae, H. influenzae, S. aureus, etc.), and environmental agents (air pollution, smoking etc.). Children aged <5 years, pregnant women, elderly, and comorbid persons have an increased risk of severe ARI outcomes. Healthcare workers (HCWs) are at a higher risk of exposure to ARIs compared to the general population. HCWs may also transmit these ARIs to their patients, colleagues, and social networks.  

The most common occupational infections of concern among HCWs are viral respiratory infections (influenza, coronaviruses, etc.), tuberculosis, and hepatitis B and C. 

This study focusses on viral ARIs due to their high transmissibility, severe outcomes among those vulnerable, challenges with diagnostics and therapies. Further, limited data exists on the burden of ARIs among HCWs. In 2016, Kenya Immunization Technical Advisory Group (KENITAG) found little data to support proposals for HCWs flu vaccination. 

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Study Objectives

Objective I

Estimating the annual incidence of ARI associated with influenza, SARS-CoV-2, RSV, and other respiratory viral pathogens among HCWs 

Objective II

Determining factors associated with incidence and severity of pathogen and non-pathogen specific ARI among HCWs 

Objective III

Estimating the economic costs associated with ARIs among HCWs

Objective IV

Describing healthcare seeking practices among HCWs with ARIs  

Determining the immune responses and kinetics of infection by influenza, SARS-CoV-2, RSV, and other respiratory viral pathogens among HCWs 

Methodology Overview

The study employs a pragmatic cluster-randomized design integrated within routine immunization systems to ensure real-world applicability and scalability.

 
Study Areas & Cluster Selection

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Funder
cdc logo
Centers for Disease Control and Prevention (CDC)
Media & Visual Evidence
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